The Stress-Gut-Skin Axis in Chronic Hives: Mechanistic Review and Homeopathic Perspective

Author(s)	Dr. Nishantpuri Gosai, Dr. Prakash Joshi
Country	India
Abstract	Chronic urticaria remains one of dermatology's most frustrating puzzles, largely because a substantial proportion of cases carry no identifiable allergic, infective, or autoimmune trigger. This article reviews two converging internal mechanisms that are increasingly implicated in these so-called idiopathic presentations: a nervous-system pathway, in which psychological stress activates cutaneous mast cells directly through corticotropin-releasing hormone and Substance P, and a gastrointestinal pathway, in which dietary histamine intolerance and gut microbial dysbiosis independently sensitise the same mast cell population. The two mechanisms are shown to interact rather than operate in isolation, with chronic stress itself capable of degrading gut barrier integrity and amplifying the internal trigger load. The article then examines the homeopathic approach to chronic urticaria, which has, through individualised case-taking, long treated emotional causation and digestive constitution as central rather than incidental to remedy selection, and reviews the published clinical evidence supporting this approach alongside its acknowledged limitations.
Keywords	chronic urticaria, psychosomatic, stress-skin axis, histamine intolerance, gut dysbiosis, homeopathy.
Field	Medical / Pharmacy
Published In	Volume 7, Issue 10, October 2026
Published On	2026-10-04

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