Recent Advances in Nano formulation for Targeted Drug Delivery

Author(s)	Praveen Gujjula, A. Divya Sri, D. Mohan, L. Renuka, P. Gowtami
Country	India
Abstract	Nanoformulations are reshaping targeted drug delivery by improving payload stability, enabling controlled release, and achieving tissue- or cell-specific localization. From advances in lipid nanoparticles (LNPs) that enabled the mRNA vaccine revolution to engineered extracellular vesicles (EVs), biomimetic coatings, stimuli-responsive materials, and nanoparticle-enabled CRISPR delivery, the 2023–2025 period has seen accelerated translation and new technical strategies for organ-selective delivery. This review summarizes design principles, notable technological innovations (2023–2025), applications, and translational bottlenecks—focusing on strategies that increase specificity, safety, and manufacturability. We highlight key recent studies and propose directions likely to drive clinical translation over the next five years.
Keywords	nanoformulation, targeted drug delivery, lipid nanoparticles, extracellular vesicles, CRISPR delivery, biomimetic coatings, stimuli-responsive nanoparticles.
Field	Medical / Pharmacy
Published In	Volume 6, Issue 11, November 2025
Published On	2025-11-28
DOI	https://doi.org/10.70528/IJLRP.v6.i11.1852
Short DOI	https://doi.org/hbfmjz

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