Molecularly Imprinted MXene-Based Biosensor for Selective and Sensitive Bilirubin Detection

Author(s)	Sahil Dahiya
Country	India
Abstract	The development of a reliable sensor requires integrating a suitable sensing platform with an efficient bio-recognition element. In this work, MXene was employed as the sensing platform and molecular imprinting as the bio-recognition strategy. This design enhanced both sensitivity and shelf life by avoiding enzymes, antibodies, or other biological molecules as receptors. Bilirubin-imprinted cavities exhibited high selectivity for bilirubin detection in human serum and synthetic samples, achieving a limit of detection (LOD) of 0.002 mg/dL, a sensitivity of 69.6 μA (log(mg/dL)⁻¹)cm⁻², and a limit of quantification (LOQ) of 6.6 mg/dL. With a relative standard deviation (RSD) of 1.2%, the sensor showed excellent inter- and intra-day repeatability. However, stability was limited to 30 days due to pristine MXene’s tendency to oxidize and agglomerate from surface –OH groups. Future improvements may involve MXene-based composites for enhanced stability and conductive monomers such as pyrrole to optimize molecular imprinting and sensor performance.
Keywords	Bio-Sensor, Bilirubin Detection, LOD, MXene
Published In	Volume 6, Issue 2, February 2025
Published On	2025-02-08

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